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Department of Biochemistry

Overview

The department of Biochemistry was established in the year 2008. The main objective of the department is to provide deep insight into the fundamental concepts in biochemistry and to equip students with biological knowledge enabling them to explore a wide range of opportunities in biological fields. Our undergraduate programme is uniquely framed with balanced theoretical and practical courses following CBCS. Our postgraduate programme is aimed at equipping skills in different experiments to address specific problems. This would cater to the needs of clinical laboratory, industrial requirements and entrepreneurship.

The Department has well equipped undergraduation, postgraduation and Research labs with sophisticated instruments such as Inverted Microscope, Fluorescent Microscope, Fluorimeter, UV Spectrophotometer, Microplate reader, Lyophiliser, Rotary Evaporator, chemi-doc etc.

In addition, we have a well-established Animal House Facility approved by CPCSEA with a functioning IAEC. The facility houses different rodent models for training and research purposes. We have conducted ICMR/KAHE funded workshops in animal handling. To maintain a pathogen free environment for immunocompromised strains, we have Individual Ventilated Cages (IVC). The department also hosts animal tissue culture laboratory (ATC) with state-of-the-art facilities such as biosafety cabinet, CO2 incubator, inverted phase-contrast microscope, deep-freezer, liquid nitrogen containers to study the cell-based research objectives. The department routinely conducts guest lectures, seminars, conferences and workshops funded by DBT, DST, TNSCST, ICMR and INSA.

All the faculties hold PhD degree in diverse fields of biochemistry with good experience in teaching and research. Our students are placed in reputed institutions/organizations to pursue advanced training/career. The department encourages students to take part in sports, extracurricular and extension activities. The department has so far completed 5 major research projects funded by ICMR, UGC, DST and 3 minor research projects funded by UGC and KAHE.

The research findings of the faculty members and students have been published in reputed international journals. At present the department has published more than 200 research articles. The major thrust area of research includes Diabetes, Cancer Biology, Phytomedicine, Nanomedicine and Computational Biology.

Vision

  • To provide scientific research at the highest international standard, integrating cutting-edge multidisciplinary approaches to solving significant problems in biology and medicine.
  • Motivate students to develop as internationally competitive professionals with excellent leadership, communication with teamwork skills.

Mission

  • To provide a high quality education and learning experience for our undergraduate and postgraduate students through.
    1. The innovative teaching methods and emphasis on the development of critical thinking and problem-solving skills.
    2. The provision of an inspiring, exciting and collaborative scientific environment.
    3. Building a rich collegial atmosphere that will equip our graduates with transferable skills and an awareness of research ethics.
  • To provide opportunities for career development for both students and staff.
  • To contribute the public to lead better life through extension activities.
  • To translate our discoveries into meaningful applications for better healthcare and economic development of nation.

Programme

Programmes

  1. Under Graduate Programme
    • B.Sc. Biochemistry
  1. Post Graduate Programme
    • M.Sc. Biochemistry (Strength: 30)
  1. Research Programmes
    • M.Phil Biochemistry
    • Ph.D. Biochemistry

Curriculum

Faculty

Name Qualification Designation Email ID Profile
Dr. V. K. Gopalakrishnan Professor
Dr.M.Sridhar Muthusami M.Sc., M.Phil., Ph.D., SET. Associate Professor sridhar.m@kahedu.edu.in Click Here
Mr. S. Rajamanikandan M. Sc., M. phil., Ph. D. Associate Professor
Dr.A.Ramakrishnan M.Sc., Ph.D Assistant Professor ramakrishnan.a@kahedu.edu.in Click Here
Dr.Kongkona Saikia M.Sc.,Ph.D. Assistant Professor kongkonasaikia.sobhasaikia@kahedu.edu.in Click Here
Dr.Rathi M.A M.Phil.,Ph.D. Assistant Professor rathi.muthaiyan@kahedu.edu.in Click Here
Dr.Femil Selta D M.Sc., M.Phil., Assistant Professor femilselta.danielraja@kahedu.edu.in Click Here
Dr.K.Surekha M.Sc.,M.Phil.,Ph.D.,B.Ed., Assistant Professor surekha.kannan@kahedu.edu.in Click Here
Dr.M.Bharathi Ph.D Assistant Professor bharathi.m@kahedu.edu.in Click Here
Mrs.P. Nirmala Devi Assistant Professor nirmaladevi.panneerselvam@kahedu.edu.in

Infrastructure

Facilities laboratories List

  • UG Biochemistry Lab I & II
  • PG Biochemistry Lab
  • Research Laboratory
  • Animal Tissue Culture Lab
  • Animal House of in vivo animal studies

Major Research Equipments

S. No Name of the Equipment
1 ELISA Reader
2 Thermal Cycler
3 Horizontal and Vertical Electrophoresis Unit
4 Wet Transfer Unit
5 Semi-dry Transfer Unit
6 Laminar Chamber for Animal Tissue Culture
7 CO2 Incubator
8 Inverted Phase Contrast Microscope
9 Fluorescence Microscope
10 Orbital Shaker
11 Rotary Evaporator
12 Laminar Chamber for Microbiology
13 Refrigerated centrifuge
14 Millipore Water System
15 Photo Fluorimeter
16 Centrifuge (4 bucket)
17 Colorimeter
18 Soxhlet Apparatus
19 Magnetic Stirrer
20 Incubator
21 Conductivity meter
22 Water bath
23 Electronic balance
24 Microscope
25 Hot air oven
26 Cyclo mixer
27 pH meter
28 Lyophilizer (Borg Scientific)
29 Bio-rad gel documentation (Biorad)
30 Individual Ventilated Caging System (IVC)
31 Cooling Microcentrifuge

Publications

Paper publications by the Faculty Members

Best Five Papers Faculty wise:

Dr.K.Poornima

  1. Kannappan Poornima, Chella Perumal Palanisamy, Sowmya Sundaram & Gopalakrishnan Velliyur Kanniappan (2017) Chromatographic Fingerprinting Analysis of Secondary Metabolites Present in Ethanolic Extract of Tabernaemontana divaricata (L.) R. Br. by HPTLC Technique, Analytical Chemistry Letters, 7:1, 20-29, DOI: 10.1080/22297928.2017.1284608
  2. Gebrehiwot TY, Chaithanya KK, Hagos Z, Hiruy M, Poornima K, Kamalakararao K, Gopalakrishnan VK. Phytochemical screening and in vitro antioxidant activities of ethanolic leaf extract of Anogeissus leiocarpa. Drug Invent. Today. 2020 Jun 1;13(6):903-8.
  3. Bhaskaran SK, Kannappan P, Muneeswari P, Madathil SR. Hepatoprotective effect of Azolla microphylla on isoproterenol-induced rats and the identification of active compound through HPTLC and GC-MS analysis. Cardiovasc Hematol Agents Med Chem. 2020 Aug 11. doi: 10.2174/1871525718666200811165322. Epub ahead of print. PMID: 32787751.
  4. Poornima K, Chella Perumal P, Gopalakrishnan VK. Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats. Biomed Res Int. 2014;2014:240243. doi: 10.1155/2014/240243. Epub 2014 Jul 17. PMID: 25136566; PMCID: PMC4124838.
  5. Bhaskaran SK, Kannappan P. Protective effect of Azolla microphylla on biochemical, histopathological and molecular changes induced by isoproterenol in rats. Biomed Pharmacother. 2017 May;89:473-481. doi: 10.1016/j.biopha.2017.01.177. Epub 2017 Feb 27. PMID: 28249249.

Dr. M. Sridhar Muthusami

  1. Krishnan A, Muthusami S. Hormonal alterations in PCOS and its influence on bone metabolism. J Endocrinol. 2017 Feb;232(2): R99-R113. doi: 10.1530/JOE-16-0405. Epub 2016 Nov 28. PMID: 27895088.
  2. Muthusami S, Kumaran RI, Babu KN, Krishnamoorthy S, Guruswamy A, Queimado L, Chaudhuri G, Ramachandran I. Role of inflammation in the development of colorectal cancer. Endocr Metab Immune Disord Drug Targets. 2020 Sep 8. doi: 10.2174/1871530320666200909092908. Epub ahead of print. PMID: 32901590.
  3. Muthusami S, Vidya B, Shankar EM, Vadivelu J, Ramachandran I, Stanley JA, Selvamurugan N. The Functional Significance of Endocrine-immune Interactions in Health and Disease. Curr Protein Pept Sci. 2020;21(1):52-65. doi: 10.2174/1389203720666191106113435. PMID: 31702489.
  4. Muthusami S, Prabakaran DS, Yu JR, Park WY. EGF-induced expression of Fused Toes Homolog (FTS) facilitates epithelial-mesenchymal transition and promotes cell migration in ME180 cervical cancer cells. Cancer Lett. 2014 Sep 1;351(2):252-9. doi: 10.1016/j.canlet.2014.06.007. Epub 2014 Jun 24. PMID: 24971934.
  5. Muthusami S, Prabakaran DS, Yu JR, Park WY. FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells. J Cancer Res Clin Oncol. 2015 Feb;141(2):203-10. doi: 10.1007/s00432-014-1802-4. Epub 2014 Aug 24. PMID: 25151576.

Dr. L. Hariprasath

  1. Periyasamy L, Muruganantham B, Deivasigamani M, Lakshmanan H, Muthusami S. Acetogenin Extracted from Annona muricata Prevented the Actions of EGF in PA-1 Ovarian Cancer Cells. Protein Pept Lett. 2020 Sep 16. doi: 10.2174/0929866527666200916141730. Epub ahead of print. PMID: 32938339.
  2. Deivasigamani M, Kannan N, Sekar N, Lakshmanan H. Safety assessment of ethanolic root extract of Zaleya decandra (EEZD) in Wistar rats. Regul Toxicol Pharmacol. 2021 Feb;119: 104822. doi: 10.1016/j.yrtph.2020.104822. Epub 2020 Nov 17. PMID: 33217502.
  3. Lakshmanan H, Raman J, David P, Wong KH, Naidu M, Sabaratnam V. Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A
  4. Shair OHM, Alharbi SA, Chinnathambi A. Apoptotic induction and anti-metastatic activity of eugenol encapsulated chitosan nanopolymer on rat glioma C6 cells via alleviating the MMP signaling pathway. J Photochem Photobiol B. 2020 Jan;20 3:111773. doi: 10.1016/j.jphotobiol.2019.111773. Epub 2020 Jan 2. PMID: 31931385.
  5. Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int J Nanomedicine. 2015 Sep 18 ;10:5853-63. doi: 10.2147/IJN.S88371. PMID: 26425086; PMCID: PMC4583117.

Dr. A. Ramakrishnan

  1. A, Vijayakumar. N, 2017, Urea Cycle Pathway Targeted Therapeutic Action of Naringin Against Ammonium Chloride Induced Hyperammonemic Rats, Biomed. Pharmacother. 94:1028-1037. (Impact factor: 3.45)
  2. A, Vijayakumar. N, Renuka. M, 2016, Naringin Regulates Glutamate-Nitric Oxide cGMP Pathway in Ammonium Chloride Induced Neurotoxicity, Biomed. Pharmacother. 84:1717-1726. (Impact factor: 3.45)
  3. A, Vijayakumar. N, Renuka. M, 2016, Effect of Naringin on Ammonium Chloride-Induced Hyperammonemic Rats: A Dose-Dependent Study. J. Acute Med. 6 (2016) 55-60. (Impact factor: 0.35)
  4. N, Renuka. M, Ramakrishnan. A, 2016, Review: Clinical Aspects of Urea Cycle Dysfunction and Altered Brain Energy Metabolism on Modulation of Glutamate Receptors and Transporters in Acute and Chronic Hyperammonemia. Biomed, Pharmacother. 81:192-202. (Impact factor: 3.45).
  5. Antioxidant Levels Instreptozotocin Induced Diabetic Rats, J. Chem. Pharm. Res. 7:831-839.

Dr. P. Rajesh

  1. Sivasankaran Ayyaru, Rajesh Pandiyan, Young Ho Ahn, Fabrication and Characterization of Anti-Fouling and Non-Toxic Polyvinylidene Fluoride-Sulphonated Carbon Nanotube Ultrafiltration Membranes for Membrane Bioreactors Applications. Chemical Engineering Research and Design, (2019). 142: 176-188. Impact factor: 3.073.
  2. Rajesh Pandiyan, Shanmugam Mahalingam, Young Ho Ahn, Antibacterial and photocatalytic activity of hydrothermally synthesized SnO2 doped GO and CNT under visible light irradiation. Journal of Photochemistry and Photobiology B: Biology, (2019). 191: 18-25. Impact factor: 4.067.
  3. Rajesh Pandiyan, Sivasankaran Ayyaru, Young Ho Ahn, Non-toxic properties of TiO2 and Stio2 Nanocomposite PES Ultrafiltration Membranes for application in membrane-based Environmental Biotechnology. Ecotoxicology and Environmental Safety, (2018). 158: 248-255. Impact factor: 4.527.
  4. Natarajan Krishnan, Abraham George Chelliah, Rajesh Pandiyan, Nivas Duraisamy, Rajesh Kannan Velu, Balasubramanian Velramar. Effect of biogenic Silver Nanocubes on Matrix Metalloproteinases 2 and 9 Expressions in Hyperglycemic Skin Injury and its Impact in Early Wound Healing in Streptozotocin-Induced Diabetic Mice, Materials Science and Engineering C., (2018). 91: 146-152. Impact factor: 4.959.
  5. Parim Brahma Naidu, Ramavat Ravindar Naik, Pothani Suresh, Balaji Meriga, Mustapha Shabana Begum, Rajesh Pandiyan, Ganapathy Saravanan. Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats. Molecular and Cellular Endocrinology., (2016). 419: 139-147. Citation: 26. Impact factor: 3.871.

Dr. E. Brindha

  1. Brindha. E, Rajasekara Pandian. M, Phytic Acid Prevents Isoproterenol- Induced Oxidative Stress in Myocardial Infarcted Rats, International Journal of Innovative Research in Pharmacy and Biological Science (IJIRPBS) Vol– 1. Issue – 1. June 2014.
  2. Brindha. E, Rajasekapandiyan. M, Preventive Effect of Phytic Acid on Lysosomal Hydrolases in Normal and Isoproterenol-Induced Myocardial Infarction in Wistar Rats, Toxicol Mech Methods. 2015 Jan 5:1-20 (Impact Factor: 1.347).
  3. Brindha. E, Rajasekapandiyan. M, Protective Role of Phytic Acid on Cardiac Mitochondrial Enzymes during Isoproterenol-Induced Myocardial Infarction in Rats, International Research Journal of Pharmaceutical and Biosciences. 2015 2(2); 21-31.
  4. Brindha. E, Rajasekapandiyan. M, Phytic acid Ameliorates Mitochondrial Lipid Peroxides, Antioxidants and Lipids in Isoproterenol-Induced Myocardial Infarction in Wistar Rats, International Research Journal of Pharmaceutical and Biosciences.2015 2(2); 10-20.
  5. Brindha. E, Rajasekapandiyan. M, Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar rats: Int J Biomed Sci. 2015 11(1); 35-41.

Dr. D. Malarvizhi

  1. Periyasamy L, Muruganantham B, Deivasigamani M, Lakshmanan H, Muthusami S. Acetogenin Extracted from Annona muricata Prevented the Actions of EGF in PA-1 Ovarian Cancer Cells. Protein Pept Lett. 2020 Sep 16. doi: 10.2174/0929866527666200916141730. Epub ahead of print. PMID: 32938339.
  2. Deivasigamani M, Kannan N, Sekar N, Lakshmanan H. Safety assessment of ethanolic root extract of Zaleya decandra (EEZD) in Wistar rats. Regul Toxicol Pharmacol. 2021 Feb;119:104822. doi: 10.1016/j.yrtph.2020.104822. Epub 2020 Nov 17. PMID: 33217502.
  3. Anusooriya P, Malarvizhi D, Gopalakrishnan VK, Devaki K. Antioxidant and Antidiabetic Effect of Aqueous Fruit Extract of Passiflora ligularis Juss. on Streptozotocin Induced Diabetic Rats. Int Sch Res Notices. 2014 Dec 21;2014:130342. doi: 10.1155/2014/130342. PMID: 27350966; PMCID: PMC4897570.
  4. Deivasigamani M, Chandrasekar AK, Muthusami S, Kanniappan GV, Lakshmanan H. Zaleya decandra exerts anti-cancer activity in HCT-116 cancer cells by impairing mitochondrial activity. Bangladesh Journal of Pharmacology. 2019 Oct 1;14(4).

Dr. P. Suganyadevi

  1. Suganyadevi P, Saravanakumar KM, Mohandas S. The antiproliferative activity of 3-deoxyanthocyanins extracted from red sorghum (Sorghum bicolor) bran through P⁵³-dependent and Bcl-2 gene expression in breast cancer cell line.
  2. Devi PS, Kumar MS, Das SM. DNA damage protecting activity and free radical scavenging activity of anthocyanins from red Sorghum (Sorghum bicolor) Bran. Biotechnology research international. 2012;2012.
  3. Devi PS, Saravanakumar M, Moh S. The effects of temperature and pH on stability of anthocyanins from red sorghum (Sorghum bicolor) bran. African Journal of Food Science. 2012 Dec 31;6(24):567-73.
  4. Reshmi SK, Aravindhan KM, Devi PS. The effect of light, temperature, pH on stability of betacyanin pigments in Basella alba fruit. Asian Journal of Pharmaceutical and Clinical Research. 2012;5(4):107-10.
  5. Saravanakumar M, Aravindhan KM. The effect of light, temperature, pH on stability of anthocyanin pigments in Musa acuminata bract. Research in plant biology. 2011 Dec 15;1(5).

Mr. T. Gobinath

  1. Mohan S, Gobinath T, Salomy A, Nisha M, Kandasamy M, Essa MM, Jayachandran KS, Anusuyadevi M. Biophysical interaction of resveratrol with sirtuin pathway: Significance in Alzheimer’s disease. Front Biosci (Landmark Ed). 2018 Mar 1;23:1380-1390. doi: 10.2741/4650. PMID: 29293440.
  2. RethnaPriya E, Ravichandran S, Gobinath T, Tilvi S, Devi SP. Functional characterization of anti-cancer sphingolipids from the marine crab Dromia dehanni. Chem Phys Lipids. 2019 Jul;221:73-82. doi: 10.1016/j.chemphyslip.2019.03.010. Epub 2019 Mar 25. PMID: 30922836.
  3. Thilagar G, Samuthirapandian R. Chitosan from crustacean shell waste and its protective role against lead toxicity in Oreochromis mossambicus. Toxicol Rep. 2020 Feb 8;7:296-303. doi: 10.1016/j.toxrep.2020.02.006. PMID: 32071883; PMCID: PMC7016161.
  4. Gobinath T, Kaviya K, Ravichandran S. Chitosan/Ulva lactuca polysaccharide Hydrogel containing copper (II) beneficial for Biofilm-associated wound infection: Formulation Characterizations and in vitro study. Research Journal of Pharmacy and Technology. 2020 Sep 1;13(9):4224-30.
  5. Gobinath T, Ravichandran S. Brain pathology in Adult Rats Treated with Tetrodotoxin.  Saudi Journal of Pathology and Microbiology. 2019 Nov 4; 11; 846-848.

Events

Conference / Workshop / Guest Lecture

  1. The Department organized a webinar on “Bioenergetics” on 11.01.2021. Dr. A. Arunkumar, Director, Bio Ages Innovations, Coimbatore delivered a lecture about Bioenergetics.
  2. A webinar on the Application of Nanotechnology in Agriculture was presented by Dr. R. Subbaiya, Associate Professor, The Copperbelt University, Kitwe, Zambia on 05.01.2021.
  3. An online session on “Identifying Intellectual Property Component at the Early Stage of Innovation” was conducted by the Department of Biochemistry and Institutions Innovation Council of KAHE on 23rd December 2020. The experts Ms. Divya Sridharan and Ms. G. Shrividhya, who are currently working in the IPR search and drafting sector (independent Indian Patent Agents) were invited.
  4. A webinar was organized by the Department of Biochemistry on 20th November 2020 to commemorate World Diabetes Day (14th November 2020) with the theme “The Nurse and Diabetes”. Dr. P. Kalaiselvi, Associate Professor, Department of Medical Biochemistry, Dr. ALM PGIBMS, University of Madras delivered the lecture on the importance and activities to be followed to avoid diabetes.
  5. A webinar was organized by the Department of Biochemistry on 6th November 2020.
    Our distinguished alumni Dr. Sreenath Kunnathupara Bhaskaran, Senior Unit Manager in Poultry Forming Lab, Almarai Company, Saudi Arabia, delivered the lecture on the “Opportunities for Biochemist Abroad”.
  6.  The department of Biochemistry has organized a webinar entitled “Shedding Light on Asymptomatic Typhoid Carriers on 8th August 2020. The lecture was delivered by Dr. B. Senthilkumar, Associate Professor of Medical Microbiology, Haramaya University, Ethiopia.
  7. As part of the World Environment Day awareness creation, our department has organized a webinar entitled “Advanced Solutions in Gas Chromatography to ascertain Environmental health on 4th June 2020.
  8. A guest lecture on “Overcoming COVID-19 Hurdles in Clinical Practice and Vaccine Development”. Dr. Palanikumar Manoharan, Senior Research Scientist, PPD Global Central Lab (CRO), Highland Heights, Kentucky, USA who is currently handling vaccine development for the MODERNA Inc (a biopharmaceutical company), was invited to give a webinar on 1st June 2020.
  9. A webinar on “IPR Basics and Indian Patent System” was organized on 14th May 2020 between 4 and 5 pm IST. Ms. Divya Sridharan, Independent Consultant, Registered Patent Agent, Chennai briefed the participants about the fundamentals and types of IPR, the filing system in India.
  10. National Conference on “Research Methodology for Life Sciences” conducted on March 04, 2020 and March 05, 2020.
  11.  National seminar on “Current Approaches to Curtail Cancer Progression” conducted on February 17, 2020 and February 18, 2020.
  12. Association inauguration and Guest lecture by Prof. N. Angayarkanni on “Diabetic retinopathy” conducted on August 03, 2018.
  13. Guest lecture by Mr. S. Syed, Professional Infotech, Coimbatore on “Health care opportunities for life science students conducted on June 20, 2018.
  14. International Conference on “Biochemical Understanding of Cancer Cell Survival and Progression” conducted from February 05, 2018 to February 07, 2018.
  15. Vision Screening Camp was conducted from January 03, 2018 to January 04, 2018.
  16. Diabetes screening campaign was conducted on November 14, 2017.
  17. World food day was celebrated on October 25, 2017.
  18. National Seminar on “Indigenous herbs and Bone Health” conducted on June 21, 2017 and June 22, 2017.
  19. Work on Understanding Bioinformatics to analyse Biological Information conducted by the Department of Biochemistry on February 17, 2017 and February 18, 2017.
  20. DST sponsored National Seminar on “Diabetes-Research and Remedies” conducted on January 27, 2017 and January 28, 2017.
  21. Guest lectures delivered by Dr. E. M. Shankar and Dr. A. Sureshkumar on January 06, 2017.

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