Department of Biochemistry

Department of Biochemistry was established on September 18, 1995. The main objective of the course is to provide deep insight in biochemistry and equip students with basic biological knowledge, and also to provide in-depth exposure to the different research works, which will help the students to get placed in, varied disciplines of life sciences. PG course in biochemistry was started in the year 1999, subsequently followed by Ph.D programme. The Department has well equipped UG, PG and Research labs with sophisticated instruments such as Inverted Microscope, Flourescent Microscope, Fluorimeter, UV Spectrophotometer, Microplate reader etc., In addition we have well established Animal House approved by IAEC and Animal Tissue Culture lab. From the inception of the department we concentrated more on teaching, learning, and evaluation by conducting more number of guest lectures, seminars, conferences and workshops.
We have conducted 1 International and 16 national level seminars and symposiums. The students were shaped by taking part in extracurricular and extension activities. In the Department we have completed 5 major research projects funded by ICMR, UGC, DST and 3 minor projects funded by UGC and Karpagam Academy of Higher Education. As a credit we have published more than 200 research articles. At present the Department has one major project funded by DST-WOSA. The major thrust area of research includes Diabetes, Cancer Biology, Phytomedicine, Nanomedicine and Computational Biology.


Vision

  • To provide scientific research at the highest international standard, integrating cutting-edge multidisciplinary approaches to solving significant problems in biology and medicine.
  • Motivate students to develop as internationally competitive professionals with excellent leadership, communication with teamwork skills.

Mission

  • To provide a high quality education and learning experience for our undergraduate and postgraduate students through.
    1. The innovative teaching methods and emphasis on the development of critical thinking and problem-solving skills.
    2. The provision of an inspiring, exciting and collaborative scientific environment.
    3. Building a rich collegial atmosphere that will equip our graduates with transferable skills and an awareness of research ethics.
  • To provide opportunities for career development for both students and staff.
  • To contribute the public to lead better life through extension activities.
  • To translate our discoveries into meaningful applications for better healthcare and economic development of nation.

Programmes

  1. Under Graduate Programme
    • B.Sc. Biochemistry
  1. Post Graduate Programme
    • M.Sc. Biochemistry
  1. Research Programme
    • Ph.D. Biochemistry

Syllabus and Curriculum

 

Name Qualification Designation Email ID
Dr.K.Pooranima M.Sc., M.Phil., Ph.D., B.Ed., PGDMLT., SLET. Professor poornima.k@kahedu.edu.in
Dr.M.Sridhar Muthusami M.Sc., M.Phil., Ph.D., SET. Associate Professor sridhar.m@kahedu.edu.in
Dr.L.Hariprasath M.Sc., Ph.D. Assistant Professor hariprasath.l@kahedu.edu.in
Dr.A.Ramakrishnan M.Sc., Ph.D Assistant Professor ramakrishnan.a@kahedu.edu.in
Dr.P.Rajesh M.Sc., Ph.D. Assistant Professor drrajeshpandiyan@kahedu.edu.in
Dr.E.Brindha M.Sc., M.Phil., Ph.D. Assistant Professor drbrindha.e@kahedu.edu.in

 

Facilities laboratories List

  • UG Biochemistry Lab I & II
  • PG Biochemistry Lab
  • Research Laboratory
  • Animal Tissue Culture Lab
  • Animal House of in vivo animal studies

Major Research Equipments

S. No Name of the Equipment
1 ELISA Reader
2 Thermal Cycler
3 Horizontal and Vertical Electrophoresis Unit
4 Wet Transfer Unit
5 Semi-dry Transfer Unit
6 Laminar Chamber for Animal Tissue Culture
7 CO2 Incubator
8 Inverted Phase Contrast Microscope
9 Fluorescence Microscope
10 Orbital Shaker
11 Rotary Evaporator
12 Laminar Chamber for Microbiology
13 Refrigerated centrifuge
14 Millipore Water System
15 Photo Fluorimeter
16 Centrifuge (4 bucket)
17 Colorimeter
18 Soxhlet Apparatus
19 Magnetic Stirrer
20 Incubator
21 Conductivity meter
22 Water bath
23 Electronic balance
24 Microscope
25 Hot air oven
26 Cyclo mixer
27 pH meter

Paper publications by the Faculty Members

Best Five Papers Faculty wise:

Dr.K.Poornima

  1. Sreenath. K.B, and Poornima, K. 2017. Protective effect of Azolla microphylla on biochemical, histopathological and molecular changes induced by isoproterenol in rats. Biomed. Pharmacother. 89: 473-481. (Impact factor: 3.457)
  2. Muneeswari, P. Deepika, S. Chella Perumal, P. Gopalakrishnan, V.K. and Poorima, K. 2016. Phytochemical screening and free radical scavenging activity of chloroform extract of Sada acuta Burm. F. Int. J. Pharmacog. Phytochem. Res. 8: 663-667. (Impact factor: 1.846)
  3. Bhaskaran, S.K. and Poornima, K. 2015. Nutritional composition of four different species of Azolla. Eur. J. Exp. Biol. 53: 6-12. (Impact factor: 0.23)
  4. Poorima, K. Chella Perumal, P. and Gopalakrishnan, V.K. 2014. Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar albino rats. BioMed. Res. Int. 240243. (Impact factor: 2.134)
  5. Poornima, K. and Gopalakrishnan, V.K. 2014. Anticancer activity of Tabernaemontana coronaria against carcinogen induced clear cell renal cell carcinoma. Chin. J. Biol. dx.dio.org/10.1155/2014 /584074.

Dr. M. Sridhar Muthusami

  1. Prabakaran. DS, Muthusamu. S, Sivaraman. T, Yu. JR, and Park. WY. 2018. Silencing of FTS increases radiosensitivity by blocking radiation-induced Notch 1 activation and spheroid formation in cervical cancer cells. Int. J. Biol. Macromol. Pii:S0141-8130(18)33509-8. (Impact factor: 3.909)
  2. Krishnan, A. and Muthusami, S. 2017. Hormonal alterations in PCOS and its influence on bone metabolism. J. Endocrinol. 232: 99-113. (Impact factor: 4.706)
  3. Seong da, B. Hong, S. Muthusami, S. Kim, W.D. Yu, J.R. and Park, WY. 2016. Cordycepin increases radio sensitivity in cervical cancer cells by overriding or prolonging radiation-induced G2/M Arrest. Eur. J. Pharmacol. 15: 77-83. (Impact factor: 2.896)
  4. Muthusami, S. Prabakaran, D.S. Yu, J.R. and Park, W.Y. 2015. FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells. J. Cancer Res. Clin. 141: 203-210. (Impact factor: 3.141)
  5. Muthusami, S, Prabakaran, D.S. Yu, J.R. and Park, W.Y. 2014. EGF-induced expression of fused toes homolog (FTS) facilitates epithelial-mesenchymal transition and promotes cell migration in ME180 cervical cancer cells. Cancer Lett. 351: 252-259. (Impact factor: 6.375)

Dr. L. Hariprasath

  1. Neeranjini. N, Chia. Wei P, Syntyche. L.S, Asweni. B, Hariprasath. L, Sri Nurestri. A.B, Vikineswary. S. 2018. A Status Review of the Bioactive Activities of Tiger Milk Mushroom Lignosus rhinocerotis (Cooke) Ryvarden. Front. Pharmacol. (Ethnopharmacology), doi: 10.3389/fphar.2017.00998. [Impact Factor: 3.831]
  2. Rusol. Al-Bahrani, Jegadeesh. R, Hariprasath. L, Abdullah. A. Hassan, Vikineswary. S. 2017. Green synthesis of silver nanoparticles using tree oyster mushroom Pleurotus ostreatus and its inhibitory activity against pathogenic bacteria. Mater. Lett. 1: 21-25. [Impact Factor: 2.687]
  3. Hariprasath. L, R. Jegadeesh, D. Pamela, W. Kah-Hui, N. Murali and S. Vikineswary. 2016. Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: a sub-chronic toxicological assessment. J. Ethnopharmacol. 194: 1051-1059. [Impact Factor: 3.115]
  4. Hariprasath. L, Jegadeesh. R, Arjun. P, Kumaresan. K, Raaman. N, Vikineswary. S and Murali. N. 2016. Aqueous extract of Senecio candicans DC induce liver and kidney damage in a sub-chronic oral toxicity study in Wistar rats. Regul. Toxicol. Pharmacol. 79: 25-34. [Impact Factor: 2.815]
  5. Jegadeesh. R, L. Hariprasath, Priscilla A. John, Chan Zhijian, P. Vengadesh, D. Pamela, N. Murali, and S. Vikineswary. 2015. Neurite outgrowth stimulatory effects of mycosynthesized AuNPs from Hericium erinaceus (Bull.:Fr.) Pers. on pheochromocytoma (PC-12) cells. Int. J. Nanomedicine. 10: 5853-5863. [Impact Factor: 4.370]

Dr. A. Ramakrishnan

  1. Ramakrishnan. A, Vijayakumar. N, 2017, Urea Cycle Pathway Targeted Therapeutic Action of Naringin Against Ammonium Chloride Induced Hyperammonemic Rats, Biomed. Pharmacother. 94:1028-1037. (Impact factor: 3.45)
  2. Ramakrishnan. A, Vijayakumar. N, Renuka. M, 2016, Naringin Regulates Glutamate-Nitric Oxide cGMP Pathway in Ammonium Chloride Induced Neurotoxicity, Biomed. Pharmacother. 84:1717-1726. (Impact factor: 3.45)
  3. Ramakrishnan. A, Vijayakumar. N, Renuka. M, 2016, Effect of Naringin on Ammonium Chloride-Induced Hyperammonemic Rats: A Dose-Dependent Study. J. Acute Med. 6 (2016) 55-60. (Impact factor: 0.35)
  4. Vijayakumar. N, Renuka. M, Ramakrishnan. A, 2016, Review: Clinical Aspects of Urea Cycle Dysfunction and Altered Brain Energy Metabolism on Modulation of Glutamate Receptors and Transporters in Acute and Chronic Hyperammonemia. Biomed, Pharmacother. 81:192-202. (Impact factor: 3.45).
  5. Amalan. V, Vijayakumar. N, Ramakrishnan. A, 2015, p-Coumaric Acid Regulates Blood Glucose and Antioxidant Levels Instreptozotocin Induced Diabetic Rats, J. Chem. Pharm. Res. 7:831-839.

Dr. Rajesh Pandiyan

  1. Anupriya Anand, Bharadhwaj Ramesh Iyer, Chandrasekar Ponnusamy, Rajesh Pandiyan and Abimanyu Sugumaran. Design and Development of Lomustine Loaded Chitosan Nanoparticles for Efficient Brain Targeting, Cardiovascular and Hematological Agents in Medicinal Chemistry, (2020) 18(1): 1-10. Scopus and Pubmed Indexed.
  2. Sivasankaran Ayyaru, Rajesh Pandiyan, Young Ho Ahn, Fabrication and Characterization of Anti-Fouling and Non-Toxic Polyvinylidene Fluoride-Sulphonated Carbon Nanotube Ultrafiltration Membranes for Membrane Bioreactors Applications. Chemical Engineering Research and Design, (2019). 142: 176-188. Impact factor: 3.073.
  3. Rajesh Pandiyan, Shanmugam Mahalingam, Young Ho Ahn, Antibacterial and photocatalytic activity of hydrothermally synthesized SnO2 doped GO and CNT under visible light irradiation. Journal of Photochemistry and Photobiology B: Biology, (2019). 191: 18-25. Impact factor: 4.067.
  4. Rajesh Pandiyan, Sivasankaran Ayyaru, Young Ho Ahn, Non-toxic properties of TiO2 and Stio2 Nanocomposite PES Ultrafiltration Membranes for application in membrane-based Environmental Biotechnology. Ecotoxicology and Environmental Safety, (2018). 158: 248-255. Impact factor: 4.527.
  5. Natarajan Krishnan, Abraham George Chelliah, Rajesh Pandiyan, Nivas Duraisamy, Rajesh Kannan Velu, Balasubramanian Velramar. Effect of biogenic Silver Nanocubes on Matrix Metalloproteinases 2 and 9 Expressions in Hyperglycemic Skin Injury and its Impact in Early Wound Healing in Streptozotocin-Induced Diabetic Mice, Materials Science and Engineering C., (2018). 91: 146-152. Impact factor: 4.959.

Dr. E. Brinda

  1. Brindh. E, Rajasekara Pandian. M, Phytic Acid Prevents Isoproterenol- Induced Oxidative Stress in Myocardial Infarcted Rats, International Journal of Innovative Research in Pharmacy and Biological Science (IJIRPBS) Vol– 1. Issue – 1. June 2014.
  2. Brindha. E, Rajasekapandiyan. M, Preventive Effect of Phytic Acid on Lysosomal Hydrolases in Normal and Isoproterenol-Induced Myocardial Infarction in Wistar Rats, Toxicol Mech Methods. 2015 Jan 5:1-20 (Impact Factor: 1.347).
  3. Brindha. E, Rajasekapandiyan. M, Protective Role of Phytic Acid on Cardiac Mitochondrial Enzymes during Isoproterenol-Induced Myocardial Infarction in Rats, International Research Journal of Pharmaceutical and Biosciences. 2015 2(2); 21-31.
  4. Brindha. E, Rajasekapandiyan. M, Phytic acid Ameliorates Mitochondrial Lipid Peroxides, Antioxidants and Lipids in Isoproterenol-Induced Myocardial Infarction in Wistar Rats, International Research Journal of Pharmaceutical and Biosciences.2015 2(2); 10-20.
  5. Brindha. E, Rajasekapandiyan. M, Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar rats: Int J Biomed Sci. 2015 11(1); 35-41.

Conference / Workshop / Guest Lecture

1.National Conference on “Research Methodology for Life Sciences” conducted on March 04, 2020 and March 05, 2020.
2. National seminar on “Current Approaches to Curtail Cancer Progression” conducted on February 17, 2020 and February 18, 2020.
3.Association inauguration and Guest lecture by Prof. N. Angayarkanni on “Diabetic retinopathy” conducted on August 03, 2018.
4.Guest lecture by Mr. S. Syed, Professional Infotech, Coimbatore on “Health care opportunities for life science students conducted on June 20, 2018.
5.International Conference on “Biochemical Understanding of Cancer Cell Survival and Progression” conducted from February 05, 2018 to February 07, 2018.
6.Vision Screening Camp was conducted from January 03, 2018 to January 04, 2018.
7.Diabetes screening campaign was conducted on November 14, 2017.
8.World food day was celebrated on October 25, 2017.
9.National Seminar on “Indigenous herbs and Bone Health” conducted on June 21, 2017 and June 22, 2017.
10.Work on Understanding Bioinformatics to analyse Biological Information conducted by the Department of Biochemistry on February 17, 2017 and February 18, 2017.
11.DST sponsored National Seminar on “Diabetes-Research and Remedies” conducted on January 27, 2017 and January 28, 2017.
12.Guest lectures delivered by Dr. E. M. Shankar and Dr. A. Sureshkumar on January 06, 2017.