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Department of Biotechnology

Overview

Biotechnology is an important tool that can be applied to various economic sectors of special interest to developing countries, such as the production of food crops, livestock management, human health care, chemical industry and environment management. The majority of developing countries including India lack the necessary qualified manpower to exploit such technologies.
Further, Biotechnology, as practiced today, requires inputs from not only one area of biological sciences, but requires a fusion of different modern biological and technological sciences. Biotechnology has become a multi-billion dollar industry all over the world.
The Department of Biotechnology at KAHE is a center for excellence in research, established in 2001. The progress of the department is consistent over the years and presently holds many research projects funded by the UGC, DST, DBT and ICMR. During the last 10 years, the department has made all round progress and is on par with the well established departments of the KAHE. Scholars in the department are pursuing research in the areas of Nano-biotechnology, Food Technology, Fermentation Technology, Plant Tissue Culture, Animal Tissue Culture, Genetics and Molecular Biology, Microbial Technology and Phytochemistry. It is commendable to mention that the department is the proud recipient of Rs. 2.81crores from the Govt. of India for various research and development programmes. Our Department of Biotechnology has been recognized by DST-FIST for research and academic purpose. Various collaborative research projects are going on in our department with many academic and industries including
-JK Nanosolutions, Karnataka, India
-University of Hyderabad, India
-Shiraz University, Shiraz, Iran
-Nanjing Agricultural University, Nanjing, China
-East China Normal University, Shanghai, China

Programme

Programmes
  1. Under Graduate Programme
    • B.Sc. Biotechnology (Strength: 60)
  2. Post Graduate Programme
    • M.Sc. Biotechnology (Strength: 60)
  3. Research Programmes
    • M.Phil Biotechnology
    • Ph.D. Biotechnology
Curriculum

Faculty

Name Qualification Designation Email ID Profile
Dr.A.Sangilimuthu M.Sc., M.Phil.,B.Ed., Ph.D. Professor sangilimuthu.a@kahedu.edu.in Click Here
Dr.S.Balamurugan Ph.D., Associate Professor balamurugan.shanmugaraj@kahedu.edu.in Click Here
Dr.S.Barathkumar M.Sc., Ph.D. Assistant Professor barathkumar.s@kahedu.edu.in Click Here
Dr.C.Rajkuberan M.Sc., Ph.D. Assistant Professor rajkuberan.c@kahedu.edu.in Click Here
Dr.A.A.Arunkumar M.Sc., Ph.D. Assistant Professor drarunkumar.aa@kahedu.edu.in Click Here
Dr.D.Prabhu M.Sc., Ph.D. Assistant Professor prabhu.dhamodharan@kahedu.edu.in Click Here
Dr.K.Chinnadurai M.Sc., M.Phil., Ph.D. Assistant Professor chinnadurai82@gmail.com Click Here
Dr.K.Gopalakrishnan M.Sc., Ph.D. Assistant Professor gopalsurya222@gmail.com Click Here
Dr.R.Srinath M.Sc., Ph.D Assistant Professor srinath.rajeswaran@kahedu.edu.in Click Here
Mrs.A.Suchithra Assistant Professor suchithra.aruchamy@kahedu.edu.in Click Here
Dr.R.Amsaveni M.Sc., Ph.D. Assistant Professor amsabiotech@gmail.com Click Here
Dr.P.S.Reethy Ph.D. Assistant Professor reethyramadas@gmail.com Click Here
Mr.P.Balamurugan Ph.D. Assistant Professor balamurugan7694@gmail.com Click Here

Infrastructure

Infrastructure

1.Staff room – 05
2.Class room – 08

Laboratories

1.UG & PG Biotechnology labs
2.Plant Tissue culture lab
3.Microbiology lab
4.Animal Tissue culture lab
5.Research and Development lab
6.Animal house and Instrumentation lab
7.Central Instrumentation Facility
8.Drug design and development lab

Major Equipment’s

Inverted, Binocular and Trinocular Microscope, Fluorescence microscope, Phase contrast microscope, Deep Freezers, PCR, Real Time PCR, ELISA, AAS, UV-Visible Spectrophotometer, Gel documentation system, Southern Blotting Unit, Western Blotting Unit, Electrophoresis units, Walk-in Cold room, Walk-in Hot room, Cooling Centrifuge, Ultra Centrifuge, CO2, BOD and Biological Incubators, 2D PAGE system, Particle gun bombardment.

Department Library

1.Total number of reference books: 107
2.Newsletters : 15
3.Journals : 15
4.Proceedings : 22
5.Ph.D thesis : 32

Publications

Paper Publications by the Faculty Members

Best Five Papers Faculty wise:

Dr.A.SANGILIMUTHU

  1. Arumugam, G., & Alagar Yadav, S. (2024). Synergistic inhibitory actions of resveratrol, epigallocatechin-3-gallate, and diallyl trisulfide against skin cancer cell line A431 through mitochondrial caspase dependent pathway: a combinational drug approach. Medical Oncology, 41(3), 64. (Impact factor: 2.8).
  2. Lakshmanan, M., Yadav, S. A., Meti, M., Kaveri, S., Subban, R., Celestina, S. K., & Subramanyam, R. (2024). Molecular interaction studies of P3CL on bovine serum albumin through biophysical approach. Journal of Biomolecular Structure and Dynamics, 1-9. (Impact factor: 5.235).
  3. Gnanaselvan, S., Yadav, S. A., & Manoharan, S. P. (2024). Structure-based virtual screening of anti-breast cancer compounds from Artemisia absinthium—insights through molecular docking, pharmacokinetics, and molecular dynamic simulations. Journal of Biomolecular Structure and Dynamics, 42(6), 3267-3285. (Impact factor: 5.235).
  4. Manoharan, S. P., Yadav, S. A., Pandiyan, B., & Suvathika, G. (2023). Tragia plukenetii-assisted omega-decenol as potential anticancer agent: Its isolation, characterization, and validation. Applied biochemistry and biotechnology, 195(3), 1699-1722. (Impact factor: 3.1).
  5. A, Yeggoni. D.P, Devadasu. E and Subramanyam. R, 2018, Molecular binding mechanism of 5-hydroxy-1-methylpiperidin-2-one with human serum albumin, Journal of Biomolecular Structure and Dynamics, 1-8 (Impact factor: 5.235).

Dr. S. BALAMURUGAN

  1. Parthiban, S., Vijeesh, T., Gayathri, T., Balamurugan, S., Sharma, A., & Sathishkumar, R. (2023). Artificial intelligence-driven systems engineering for next-generation plant-derived biopharmaceuticals. Frontiers in Plant Science, 14: 1252166.
  2. Balamurugan, S., Khorattanakulchai, N., Panapitakkul, C., Malla, A., Im-Erbsin, R., Inthawong, M., Sunyakumthorn, P., Hunsawong, T., Klungthong, C., Reed, M. C., Kemthong, T., Suttisan, N., Malaivijitnond, S., Srimangkornkaew, P., Klinkhamhom, A., Manopwisedjaroen, S., Thitithanyanont, A., Taychakhoonavudh, S., & Phoolcharoen, W. (2022). Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity. Vaccine, 40: 4440-4452.
  3. Khorattanakulchai, N., Manopwisedjaroen, S., Rattanapisit, K., Panapitakkul, C., Kemthong, T., Suttisan, N., Srisutthisamphan, K., Malaivijitnond, S., Thitithanyanont, A., Jongkaewwattana, A., Balamurugan, S., & Phoolcharoen, W. (2022). Receptor binding domain proteins of SARS-CoV-2 variants produced in Nicotiana benthamiana elicit neutralizing antibodies against variants of concern. Journal of Medical Virology, 94: 4265- 4276.
  4. Lobato Gómez, M., Huang, X., Alvarez, D., He, W., Baysal, C., Zhu, C., Armario-Najera, V., Blanco Perera, A., Cerda Bennasser, P., Saba-Mayoral, A., Sobrino-Mengual, G., Vargheese, A., Abranches, R., Abreu, I. A., Balamurugan, S., et al. (2021) Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases. Plant Biotechnology Journal, 19: 1901-1920.
  5. Balamurugan, S., Priya, L.B., Mahalakshmi, B., Subbiah, S.,Hu, R., Velmurugan, B.,& Baskaran, R. (2020) Bacterial and viral vectors as vaccine delivery vehicles for breast cancer therapy. Life Sciences, 250:117550.

Dr. S. BARATHKUMAR

  1. Geethalakshmi, S., Barathkumar, S., & Prabu, G. (2015). The MYB transcription factor family genes in sugarcane (Saccharum sp.). Plant Molecular Biology Reporter, 33, 512-531.
  2. Sadasivam, B., & Gajjeraman, P. (2016). Characterization of Water-Deficit Stress-Responsive R2R3-MYBTranscription Factor Gene, ScMYB50/23 from Sugarcane. Indian Journal of Science and Technology, 9, 37.
  3. Giruba, K. G., Barathkumar, S., Immanuel, G., & Sivagnanavelmurugan, M. (2023). Antidiabetic effect and haematological changes in alloxan induced diabetic rats treated with trash fish, Odonus niger liver oil in comparision with cod liver oil. Biochemical & Cellular Archives, 23(1).

Dr. C. RAJKUBERAN

  1. Chandrasekaran, R., Krishnan, M., Chacko, S., Gawade, O., Hasan, S., Joseph, J., … & Jiang, H. (2023). Assessment of anticancer properties of cumin seed (Cuminum cyminum) against bone cancer. Frontiers in Oncology, 13, 1322875. (Impact factor:4.2)
  2. Alghuthaymi, M. A., Patil, S., Rajkuberan, C., Krishnan, M., Krishnan, U., & Abd-Elsalam, K. A. (2023). Polianthes tuberosa-mediated silver nanoparticles from flower extract and assessment of their antibacterial and anticancer potential: an in vitro approach. Plants, 12(6), 1261. (Impact factor: 3.7).
  3. Chandrasekaran, R., Krishnan, M., Bupesh, G., Chacko, S., Gawade, O., Hasan, S., & Sagadevan, S. (2023). Prospective features of functional 2D nanomaterial graphene oxide in the wound healing process. Journal of Drug Delivery Science and Technology, 82, 104352. (Impact factor: 5.2).
  4. Patil, S., Rajkuberan, C., & Sagadevan, S. (2023). Recent biomedical advancements in graphene oxide and future perspectives. Journal of Drug Delivery Science and Technology, 104737. (Impact factor: 5.2).
  5. Joseph, J., Kumar, S., Krishnan, M., & Chandrasekaran, R. (2024). Carthamidin-mediated silver nanoparticles synthesis, characterization and anticancer activity-Invitro Approach. (Cite score: 9.2).

Dr. A. A. ARUNKUMAR

  1. Arunkumar, Anbu Aravazhi, and Arunachalam Manimekalan. “Freshwater fish fauna of rivers of the southern Western Ghats, India.” (2018).
  2. Arunkumar, Anbu Aravazhi, Thirunavukkarasu Sivaraman, and Arunachalam Manimekalan. “Species Diversity and Habitat Inventory of Puntius sp. from Various Water Bodies of South India.” Journal of Pharmaceutical Sciences and Research 9.10 (2017): 1775-1784.
  3. ARUNKUMAR, Anbu Aravazhi, Nagaraj VIJAYA LAKSHMI, and Arunachalam “Osteological characterization of the genus Puntius (Teleostei: Cyprinidae) recorded from six river systems of southern Western Ghats, India.” Iranian Journal of Ichthyology 5.2 (2018):139-166.
  4. Chandrasekar, Divya, and Anbu Aravazhi Arunkumar. “Morphological and Osteological Characterization of Three Fish Species from River Noyyal of Coimbatore District, Tamil Nadu, India.” UTTAR PRADESH JOURNAL OF ZOOLOGY 44.23 (2023): 266-281.
  5. Priyanka, S., Athira, S.V., Shreeyashwanth, R., Arunkumar, A.A.Adsorption Of Wastewater Using Green Nanoparticles Synthesized From Murraya koenigii And Coriandrum sativum. Indian Journal of Environmental Protection, 2021, 41(3), pp. 325–332

Dr. D. PRABHU

  1. Vyas K, Prabaker S, Prabhu D, Sakthivelu M, Rajamanikandan S, Velusamy P, Su CH, Gopinath SCB, Pachaiappan R. Study of an inhibitory effect of plant polyphenolic compounds against digestive enzymes using bench-working experimental evidence predicted by molecular docking and dynamics. Int J Biol Macromol. 259(Pt 1):129222, 2024 (IF: 8.2).
  2. Sureshan M, Prabhu D, Saraboji K. Identification of anti-filarial lead compounds targeting metal binding and substrate channel residues of Cu/Zn SOD1 from Wuchereria bancrofti. J Biomol Struct Dyn. 41 (18), 8715-8728, 2023 (IF: 5.235).
  3. Park JY, Sivasankar C, Kirthika P, Prabhu D, Lee JH. Non-Structural Protein-W61 as a novel target in Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV): An in-vitro and in-silico study on protein-protein interactions with nucleoprotein and viral replication. Viruses. 15(9):1963, 2023(IF: 4.7).
  4. NM Vinita, U Devan, S Durgadevi, S Anitha, D Prabhu, S Rajamanikandan, M Govarthanan, A Yuvaraj, M Biruntha, AJA Velanganni, J Jeyakanthan, PA Prakash, MSM Jaabir, P Kumar. Triphenylphosphonium conjugated gold nanotriangles impact Pi3K/AKT pathway in breast cancer cells: a photodynamic therapy approach. Scientific Reports, 2023. (IF: 4.996).
  5. Prabhu D, Rajamanikandan S, Amala M, Saritha P, Jeyakanthan J, Ramasamy, P. Functional Characterization, Mechanism and Mode of Action of the Putative Streptomycin Adenylyltransferase from Serratia marcescens. Antibiotics (Basel), 11, 1722, 2022 (IF: 5.22).

Dr. K. CHINNADURAI

  1. Chinnadurai, K., Prema, P., Veeramanikandan, V., Kumar, K. R., Nguyen, V. H., Marraiki, N., … & Balaji, P. (2022). Toxicity evaluation and oxidative stress response of fumaronitrile, a persistent organic pollutant (POP) of industrial waste water on tilapia fish (Oreochromis mossambicus). Environmental Research, 204, 112030.
  2. Chinnadurai, K., Balaji, P., & Eyini, M. (2019). Evaluation of micronucleus assay and genotoxic effect in Oreochromis mossambicus exposed to a fumaronitrile. Toxicology International, 70-79.
  3. Balaji Paulraj. Chinnadurai Kuppusamy, Arul Ganesh, Karthikeyeni Sambanthan, Eyini Muthukumarasamy,2016, Enzyme modulation studies of Fumaronitrile on fresh water fish Oreochromis mossambicus, International Journal of Bioassays, 5050-5055.
  4. Chinnadurai, K. An investigation on the presence of persistent organic pollutants pops at different riverine sites of krishnagiri district tamilnadu and its toxicological effects on oreochromis mossambicus.

Dr. K. GOPALAKRISHNAN

  1. Islam, S., Dutta, P., Sahay, O., Gopalakrishnan, K., Muhury, S. R., Parameshwar, P., … & Santra, M. K. (2022). Feedback‐regulated transcriptional repression of FBXO31 by c‐Myc triggers ovarian cancer tumorigenesis. International Journal of Cancer, 150(9), 1512-1524. (Impact Factor: 6.4)
  2. Sravani, S., Gopalakrishnan, A., John, A. S., Ramasubramanian, R., Gopalakrishnan, K., Prabhu, N. M., … & Natarajan, S. B. (2024). Incidence of mud crab reovirus (MCRV) outbreak in polyculture ponds of Andhra Pradesh, south east coast of India. Journal of Invertebrate Pathology, 204, 108092. (Impact Factor: 3.6)
  3. Kannan, S., Ragavan, P., Gopalakrishnan, K., Salah, M., & Balasubramani, K. (2021). Mangrove floristics, forest structure and mapping of Neil Island (Andaman and Nicobar Islands, India) with emphasis on the diversity of Rhizophora species and the significance of small island mangroves. Botanica Marina, 64(3), 227-241. (Impact Factor: 1.6)
  4. Gopalakrishnan, Sivasankar Palaniappan, Sivakumar Kannan, 2021. Antimicrobial Activity of a Novel silver Nanoparticles mediated by a Marine Actinobacterium isolated from marine sediment, European Journal of Molecular & Clinical Medicine, 8(3), pp.4359-4368.
  5. Parthasarathy, S., Rajeswaran, S., Rajan, D. K., Ganesh, A., Shanmugan, P., & Gopalakrishnan, (2024). Bio-valorization of Secondary Metabolites Produced by Actinobacterium SRV02, Isolated from Shell Waste Environment Combats Clinical Bacterial Pathogens and Ameliorates Anticancer Effects Against Lung Cancer Cells. Waste and Biomass Valorization, 1-14. (Impact Factor: 3.1)

Dr. R. SRINATH

  1. Rajeswaran, S., Thirugnanasambandan, S. S., & Vilwanathan, R. (2024). Immunostimulatory Effects of Exopolysaccharide Produced by Mangrove Habitat Actinobacterium, Isolated From the Marine Environment of Tuticorin. Waste and Biomass Valorization, 1-18.
  2. Rajeswaran, S., Somasundaram Thirugnanasambandan, S., Rengasamy Subramaniyan, S., Kandasamy, S., & Vilwanathan, R. (2019). Synthesis of eco-friendly facile nano-sized zinc oxide particles using aqueous extract of Cymodocea serrulata and its potential biological applications. Applied Physics A, 125, 1-12.
  3. Sathishkumar, R. S., Sundaramanickam, A., Srinath, R., Ramesh, T., Saranya, K., Meena, M., & Surya, P. (2019). Green synthesis of silver nanoparticles by bloom forming marine microalgae Trichodesmium erythraeum and its applications in antioxidant, drug-resistant bacteria, and cytotoxicity activity. Journal of Saudi Chemical Society, 23(8), 1180-1191.
  4. Rajeswaran, S., Thirugnanasambandan, S. S., & Vilwanathan, R. (2024). Immunostimulatory Effects of Exopolysaccharide Produced by Mangrove Habitat Actinobacterium, Isolated From the Marine Environment of Tuticorin. Waste and Biomass Valorization, 1-18.
  5. Parthasarathy, S., Rajeswaran, S., Rajan, D. K., Ganesh, A., Shanmugan, P., & Kesavaperumal, G. (2024). Bio-valorization of Secondary Metabolites Produced by Actinobacterium SRV02, Isolated from Shell Waste Environment Combats Clinical Bacterial Pathogens and Ameliorates Anticancer Effects Against Lung Cancer Cells. Waste and Biomass Valorization, 1-14.

Dr. R. AMSAVENI

  1. Logpriya S., V. Bhuvaneshwari, D. Vaidehi, R. P. SenthilKumar, R. S. Nithya Malar, B. Pavithra Sheetal, R. Amsaveni, M. Kalaiselvi. (2018). Preparation and characterization of ascorbic acid‑mediated chitosan–copper oxide nanocomposite for anti‑microbial, sporicidal and biofilm‑inhibitory activity, Journal of Nanostructure in Chemistry: 8:301–309. (Impact factor-8.3).
  2. Vaidehi. D, V. Bhuvaneshwari*, R. Amsaveni, M. Kalaiselvi, A. Sivaranjini. (2017). Novel Chitosan Nanoparticles as Drug Carriers in Cancer Therapy. Journal of Polymer Materials, 34(1). (Impact factor-0.2).
  3. Amsaveni R, Sureshkumar M, Aravinth A, Mary JR, Vivekanandhan G. (2016). Production of Non-Ribosomal Peptide Synthetase (NRPS)- Dependent Siderophore by Aeromonas Isolates. Iranian Biomedical Journal, 20 (4): 235-240. (Scopus indexed).
  4. Lawrance Nelsonjoseph, Benaltraja Vishnupriya, Ramasamy Amsaveni, Devaraj Bharathi Subramani Thangabalu, Parameswaran Rehna. (2022). Synthesis and characterization of silver nanoparticles using Acremonium borodinense and their anti-bacterial and hemolytic activity, Biocatalysis and Agricultural Biotechnology, 39 (2022) 102222. (Scopus indexed).
  5. Praveen Chandran R, Kalaiselvi M, Bhuvaneshwari V, Amsaveni R, Ragavendran P. (2016). In vitro assessment of free radical scavenging activity of Jasminum grandiflorum (L.) Flower. Asian Journal of Pharmaceutical and Clinical Research, 9:1, 148-151. (Scopus indexed).

Dr.REETHY.P.S

  1. P. S. Reethy and K.V.Lalitha, 2021, Characterization of V. cholerae O1 biotype El Tor serotype Ogawa possessing the ctxB gene of the classical biotype isolated from well water associated with the cholera outbreak in Kerala, South India. Journal of Water and Health,1-10 (Impact factor: 2.5).
  2. P. S. Reethy and K.V. Lalitha, 2020, Antimicrobial resistance in Vibrio cholerae from Aquatic Environment. Fishery Technology. 58.(2021)1-10 (Impact factor 0.2)
  3. P. S Reethy and K.V.Lalitha, 2020.Phenotypic and Genotypic characterization of nonO1/nonO139 Vibrio cholerae from aquaculture farm sediments. Fishery Technology 57. (2020)128-136 (Impact factor 0.2).

Mr. P. BALAMURUGAN

  1. Pandiyan, B., Yadav, S. A., Faruck, L. H., &Bakshi, H. (2020). Metabolic profiling and biological activities of Artabotrys hexapetalus leaves. International Journal of Research in Pharmaceutical Sciences, 11(2), 2371-2382. (Scopus)
  2. Pandiyan, B., Yadav, S. A., Karpagavalli M ., Gayathiri E., Suvathika Gnanaselvan and Sowmya Priya Manoharan (2022). A Comprehensive Review on Medicinal Plants against Lung Cancer. Oriental journal of chemistry, Vol. 38, No.(3): Pg. 688-697. (WoS)
  3. Gnanaselvan, S., Yadav, S. A., Manoharan, S. P., & Pandiyan, B. (2022). Uncovering the Anticancer Potential of Phytomedicine and Polyherbal’s Synergism against Cancer–A Review. Biointerface Research in Applied Chemistry (Scopus &WoS)
  4. Manoharan, S. P., Yadav, S. A., Pandiyan, B., & Suvathika, G. (2023). Tragiaplukenetii-Assisted Omega-Decenol as Potential Anticancer Agent: its Isolation, Characterization, and Validation. Applied Biochemistry and Biotechnology, 195(3), 1699-1722. (Impact factor 3.094) (Scopus &WoS).
  5. Manoharan, S. P., Yadav, S. A., Suvathika, G., Anandhan, P., & Pandiyan, B. (2024). Screening of Phosphoinositide-3 Kinase Inhibitors from Argemone mexicana Leaves. Biomedical and Pharmacology Journal, 17(2). (Scopus).

Events

International Conference

1.International Conference on “Advances in Therapeutic Molecules and Drug Design” on January 10, 2019.

National Conferences

1.National Conference on Advance Techniques in Plant Science and Technology on February 13, 2020 and February 14, 2020.
2.National Level Competition for Bio-Science Students Becon Fest, IIT-Delhi on July 05, 2018 and July 06, 2018.
3.National Conference on “Plant Based Drugs – Biotechnological Implications” on August 10, 2017 and August 11, 2017.
4.National Conference on “Microbial Biotechnology for Sustainable Agriculture and Food Safety” on July 27, 2017 and July 28, 2017.

Workshop

1.National level Lecture Workshop on Avenues of Biotechnology to next Generation from Dynamics to Molecular mechanisms on December 19, 2019 and December 20, 2019
2.Science Academics Lecture Workshop funded by INSA-IASC-NASC, Bangalore, New Delhi on June 27, 2018 and June 28, 2018.
3.Science Academies Lecture Workshop on “Recent advances in Biological Sciences” during July 24, 2017 and July 25, 2017.

Association Meet

1.Department Association (TECHNOSTRAND) Inauguration on December 2019.
2.Department Association (TECHNOSTRAND) Inauguration on July 2018.

Faculty Development Programme

  1. Seven days national level Faculty Development Program on “Innovations in Biotechnology as Lifesaving Prospective” on August 03, 2020 to August 09, 2020

Webinar

  1. Webinar on “ITC and its data analysis using dynamic approach” on May 18, 2020
  2. Webinar on “Structural Biology: A road map to drug discovery” on May 27, 2020

Extension activities

  1. AIDS Awareness Programme for young peoples on December 01, 2020

KAHE - Karpagam Academy of Higher Education

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